Need serology?
Yes, we're still the PCR experts. But Zoologix also performs ELISA antibody tests for...

SRV
Herpes B
SIV
STLV
Measles
Hepatitis A
Hepatitis B
Hepatitis C

* * *

Zoologix performs primate infectious disease tests by PCR for...

Adenoviruses

Aspergillus

B virus

Babesia

Baboon endogenous virus

Baylisascaris procyonis

Borrelia burgdorferi

Burkholderia

Campylobacter

Chagas' disease

Chikungunya virus

Chlamydia pneumoniae

Chlamydophila trachomatis

Clostridium

Cronobacter sakazakii

Cryptosporidium

Cytomegalovirus, baboon

Cytomegalovirus, chimpanzee

Cytomegalovirus, human

Cytomegalovirus, macaque

Cytomegalovirus, simian

Dengue

E. coli O157:H7

E. coli panel

Encephalitis, Japanese

Encephalitis, St. Louis

Encephalomyocarditis (EMCV)

Entamoeba species

Enterovirus

Epstein-Barr virus

Giardia

Gibbon ape leukemia

Helicobacter

Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Herpes ateles

Herpes B virus

Herpes simplex type 1

Herpes simplex type 2

Herpes tamarinus

Herpesvirus ateles

Herpesvirus papio 1 & 2

Herpesvirus saimiri

Human adenoviruses

Human herpesviruses types 6, 7 & 8

Human immunodeficiency virus types 1 & 2

Human T cell lymphotropic virus

Human Varicella-Zoster

Influenza

Klebsiella

Lawsonia intracellularis

Leptospira

Lyme disease

Lymphocryptovirus

Malaria

Measles

Monkeypox

Mycobacteria

Mycoplasma

Neisseria gonorhoeae

Neisseria meningitidis

Papillomavirus

Parvoviruses

Plasmodium species

Reovirus screen

Rhesus rhadinovirus

Rotavirus

Salmonella

Shigella and enteroinvasive E. coli

Simian agent 6 (SA6)

Simian agent 8 (SA8)

Simian foamy virus (SFV)

Simian hemorrhagic fever (SHFV)

Simian immunodeficiency virus (SIV)

Simian parainfluenza virus

Simian retrovirus (SRV)

Simian sarcoma virus

Simian T-cell leukemia (STLV) types 1 & 2

Simian T-cell leukemia (STLV) type 3

Simian Varicella-Zoster

Squirrel monkey retrovirus

Streptococcus pneumoniae

Streptococcus pyogenes

SV40

SV5

Toxoplasma gondii

Treponema pallidum

Trichomonas/
Tritrichomonas

Trypanosoma cruzi

Tuberculosis

Ureaplasma

West Nile virus (WNV)

Yellow fever

Yersinia pestis

Yersinia pseudotuberculosis

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Genetic tests for...

A/B/AB blood type in macaques

Cynomolgus genotyping

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

smCCR5Δ24
in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements


PCR tests for Epstein Barr virus and other lymphocryptoviruses
primate assay data sheet

Lymphocryptoviruses and Epstein-Barr virus

Test codes:

S0032 - Ultrasensitive qualitative detection of Epstein-Barr virus by real time polymerase chain reaction.  This assay detects only Epstein Barr virus, not other lymphocryptoviruses.

S0079 - Ultrasensitive qualitative detection of lymphocryptoviruses by real time polymerase chain reaction.  This assay detects Epstein-Barr and other lymphocryptoviruses of clinical interest in nonhuman primates.

 

The herpesviridiae family consists of three groups: alpha, beta and gamma herpesvirus. All three groups have been found in primates including humans. Old World primates, including great apes, and New World primates have been studied extensively and found to harbor several herpesvirus species, most of them gamma herpesviruses.

The gamma herpesviruses are grouped into two classes: lymphocryptoviruses (n1) and rhadinoviruses (n2). The lymphocryptoviruses include Epstein–Barr virus, lymphocryptovirus of rhesus monkeys, and Herpesvirus papio of baboons. Rhadinoviruses that infect New World monkeys include Herpesvirus saimiri, whose natural host is the squirrel monkey, and Herpesvirus ateles, which infects spider monkeys. Rhadinoviruses that infect hominoids and Old World monkeys include Kaposi's sarcoma-associated herpesvirus, also known as HHV-8, and rhesus monkey rhadinovirus.

LCV strains isolated from different species of nonhuman primates share a high degree of similarities, both in genomic sequence and organization and in biological behavior. Even so, the various LCV strains each appear to be species specific. For example, infection of macaques or baboons with B95-8 or P3HR1 EBV strains fails to trigger any development of EBV pathogenesis. However, it is important to note that almost all wild caught primates and many captive ones have been shown to carry LCV antibodies beginning early in life. Thus, it is possible that the various LCV strains’ species specificity is actually due to cross-reactive immunity resulting from prior LCV infection. If this is the case, then given that many captive primates are immunosuppressed or infected with immunodeficiency virus, cross-species infection with different strains of LCV may be possible in these animals.

Utilities:

  • Help confirm the disease causing agent
  • Shorten the time required to confirm clinical diagnosis of a lymphocryptovirus infection
  • Help ensure that primate populations are free of lymphocryptovirus
  • Early prevention of spread of lymphocryptoviruses among a colony
  • Minimize personnel exposure to this virus
  • Safety monitoring of biological products and vaccines that derive from monkeys

Specimen requirement: 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top) tube.

For specimen types other than those listed here, please call to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative real time PCR

Normal range: Nondetected

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