Need serology?
Yes, we're still the PCR experts. But Zoologix also performs ELISA antibody tests for...

SRV
Herpes B
SIV
STLV
Measles
Hepatitis A
Hepatitis B
Hepatitis C

* * *

Zoologix performs primate infectious disease tests by PCR for...

Adenoviruses

African green monkey endogenous virus

Aspergillus

B virus

Babesia

Baboon endogenous virus

Baylisascaris procyonis

Borrelia burgdorferi

Burkholderia

Campylobacter

Chagas' disease

Chikungunya virus

Chlamydia pneumoniae

Chlamydophila trachomatis

Clostridium

Coccidioides

Cronobacter sakazakii

Cryptosporidium

Cytomegalovirus, baboon

Cytomegalovirus, chimpanzee

Cytomegalovirus, human

Cytomegalovirus, macaque

Cytomegalovirus, simian

Dengue

E. coli O157:H7

E. coli panel

Encephalitis, Japanese

Encephalitis, St. Louis

Encephalomyocarditis (EMCV)

Entamoeba species

Enterovirus

Epstein-Barr virus

Giardia

Gibbon ape leukemia

Helicobacter

Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Herpes ateles

Herpes B virus

Herpes simplex type 1

Herpes simplex type 2

Herpes tamarinus

Herpesvirus ateles

Herpesvirus papio 1 & 2

Herpesvirus saimiri

Human adenoviruses

Human herpesviruses types 6, 7 & 8

Human immunodeficiency virus types 1 & 2

Human T cell lymphotropic virus

Human Varicella-Zoster

Influenza

Klebsiella

Lawsonia intracellularis

Leishmania

Leptospira

Lyme disease

Lymphocryptovirus

Malaria

Measles

Monkeypox

Mycobacteria

Mycoplasma

Neisseria gonorhoeae

Neisseria meningitidis

Papillomavirus

Parvoviruses

Plasmodium species

Reovirus screen

Rhesus rhadinovirus

Rotavirus

Salmonella

Shigella and enteroinvasive E. coli

Simian agent 6 (SA6)

Simian agent 8 (SA8)

Simian foamy virus (SFV)

Simian hemorrhagic fever (SHFV)

Simian immunodeficiency virus (SIV)

Simian parainfluenza virus

Simian retrovirus (SRV)

Simian sarcoma virus

Simian T-cell leukemia (STLV) types 1 & 2

Simian T-cell leukemia (STLV) type 3

Simian Varicella-Zoster

Squirrel monkey retrovirus

Streptococcus pneumoniae

Streptococcus pyogenes

SV40

SV5

Toxoplasma gondii

Treponema pallidum

Trichomonas/
Tritrichomonas

Trypanosoma cruzi

Tuberculosis

Ureaplasma

Valley fever

West Nile virus (WNV)

Yellow fever

Yersinia pestis

Yersinia pseudotuberculosis

* * *

Genetic tests for...

A/B/AB blood type in macaques

Cynomolgus genotyping

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

smCCR5Δ24
in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements


Zoologix primate PCR diagnostics

ZOOLOGIX primate diagnostic testing

Why use PCR to detect primate infectious diseases?

Molecular diagnostic testing using PCR (Polymerase Chain Reaction) has revolutionized the way veterinarians, researchers, field biologists, zoos and animal care facilities maintain animal health and obtain disease data.

The sensitivity, specificity and speed with which pathogens and mutations are identified by PCR enable diagnostic, research and monitoring possibilities unavailable using other techniques. Molecular techniques represent a dramatically effective tool for the diagnosis of disease in valuable populations of nonhuman primates and other animals.

In PCR testing, nucleic acid -- DNA or RNA -- is isolated from a specimen, then amplified (after an extra reverse transcription step in the case of RNA) using highly specific primers complementary to known target sequences. Positive and negative controls are run simultaneously; internal controls monitor extraction and PCR efficiency. Each sample is run in duplicate aliquots to check repeatability. Amplification is visualized and recorded using state-of-the-art protocols and instrumentation.

How is molecular, PCR-based testing complementary to other kinds of testing?

  • Cross-reactivity reduces the specificity of many serological tests: a positive result can be caused by organisms other than the target. Molecular assays, on the other hand, are highly specific because they detect genetic sequence unique to the target pathogen. Even closely related pathogen strains can often be distinguished.
  • The influence of some sources of false positives is reduced in molecular testing, because while other testing methods detect antibodies to pathogens which may not still be present, molecular assays detect the genetic material of the pathogen itself -- a direct indication of presence of the pathogen in the sample.
  • Latent or early infections can often be detected by PCR before disease symptoms are apparent. Detection is not dependent on elevated antibody levels.
  • Animals with high titres of some viruses can actually exhibit very low antibody levels as their immune systems are challenged by an infection. This can result in false negative diagnoses if antibody testing alone is used.
  • PCR's exquisite sensitivity allows detection of a target pathogen in a sample even if present in very low titres, and even from very small sample volumes.
  • Many different sample types are appropriate for PCR testing - not just serum.  Check our assay datasheets for any test's sample requirements.

ZOOLOGIX primate genetic testing

Recent studies indicate that considerable intraspecies variation exists among common nonhuman primates.  This can be true for animals from a single region - even those from a single source. Different genotypes may perform very differently in preclinical drug trials and other research; genetic variation is now thought to be a major confounding factor in such work. Reduction of confounding genetic variations in study groups can help reduce the number of primates needed in preclinical trials and other research.

Zoologix now screens NHPs for relevant genetic polymorphisms, including...

...and other polymorphisms of interest in preclinical work. Zoologix primate genetic tests are fast, reliable and economical, and they are performed from easily-collected, easily-shipped buccal swabs (they can also be performed from blood or tissue samples).

Zoologix experts can also design and implement custom tests for your polymorphisms of interest. Contact Zoologix if you need a custom test to detect a new or proprietary polymorphism. We can perform such work under strict confidentiality arrangements if needed.

About Zoologix
Zoologix serves animal care professionals with molecular diagnostic testing for infectious diseases that affect primates and other animals. Other testing facilities perform PCR testing as a sideline. Because we specialize in PCR assays for infectious diseases of animals, our lab staff are adept at performing protocols designed to maintain specimen integrity and maximize assay specificity and sensitivity. We provide fast turnaround and competitive pricing in each of our assay categories.

Zoologix is owned and managed by board-certified scientists and seasoned laboratory managers with extensive experience in molecular biology, biochemistry, zoology, assay design, quality assurance and lab operations. Our objective is to provide to the veterinary and research communities the fastest, highest quality molecular infectious disease testing available.

Client samples are stored at our lab for six months to facilitate any followup testing.

Zoologix is headquartered in Chatsworth, in southern California. We are located near two major airports (LA International and Burbank), UCLA, USC, CalTech and other regional research centers.

Zoologix Inc.
9811 Owensmouth Avenue
Suite 4
Chatsworth CA 91311-3800
USA

Phone: 818-717-8880
Fax: 818-717-8881
Email: info@zoologix.com

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