rodent and rabbit assay data sheet
Rabbit fibroma virus
S0136 - Ultrasensitive qualitative detection of rabbit
fibromavirus by real time PCR
virus, also known as Shope fibroma virus or fibromatosis virus
of rabbits, is a poxvirus of the genus leporipoxvirus and is
closely related to vaccinia and myxoma viruses. Infection of
rabbits with this virus can result in multiple small (25 mm
diameter), firm, pinkish-red, spherical fibromas all over the
body (Strayer et al., 1983).
rabbits have been reported in a number of states and are usually
found on cottontail rabbits living east of the Mississippi
River. In Michigan, cottontail rabbits in the southern Lower
Peninsula are commonly infected.
The virus can
be transmitted between cottontail rabbits through the bites of
fleas, mosquitoes and possibly other biting insects. The
resulting loosely attached tumors occur most frequently on the
skin of the feet, nose, eyelids, lips, ears and back. The
fibroma virus acts directly on epidermal and connective tissue
cells, causing formation of a localized tumor. The tumor grows
very slowly and will regress after 10 to 12 months when the body
starts to develop antibodies.
examination may be sufficient because the characteristic size,
shape and appearance of the fibromas allow for a quick and
fairly accurate presumptive diagnosis. However, to confirm the
diagnosis molecular testing and/or histopathological examination
should be performed.
Help confirm the disease causing agent
Shorten the time required to confirm a clinical
diagnosis of rabbit fibroma virus
Help ensure that rabbit colonies or populations are free of
Early prevention of spread of this virus among a
population or in a geographic area
Minimize human exposure to this virus
Safety monitoring of biological products that derive
Cabirac, G., Sell, S. and Leibowitz, J.L. (1983) Malignant
rabbit fibroma virus: observations on the culture and
histopathologic characteristics of a new virus-induced rabbit
tumor. J. Natl. Cancer Inst. 71:91-104
0.2 ml tissue, or 0.2 ml whole blood in EDTA (purple top) or ACD
(yellow top) tube.
For specimen types other than those listed here, please call to
confirm specimen acceptability and shipping instructions.
For all specimen types, if there will be a delay in shipping, or
during very warm weather, refrigerate specimens until shipped
and ship with a cold pack unless more stringent shipping
requirements are specified. Frozen specimens should be shipped
so as to remain frozen in transit. See
shipping instructions for more information.
2 business days
real time polymerase chain reaction