Zoologix performs primate infectious disease tests by PCR for...


African green monkey endogenous virus


B virus


Baboon endogenous virus

Baylisascaris procyonis

Borrelia burgdorferi



Chagas' disease

Chikungunya virus

Chlamydia pneumoniae

Chlamydophila trachomatis



Cronobacter sakazakii


Cytomegalovirus, baboon

Cytomegalovirus, chimpanzee

Cytomegalovirus, human

Cytomegalovirus, macaque

Cytomegalovirus, simian


E. coli O157:H7

E. coli panel

Encephalitis, Japanese

Encephalitis, St. Louis

Encephalomyocarditis (EMCV)

Entamoeba species


Epstein-Barr virus


Gibbon ape leukemia


Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Herpes ateles

Herpes B virus

Herpes simplex type 1

Herpes simplex type 2

Herpes tamarinus

Herpesvirus ateles

Herpesvirus papio 1 & 2

Herpesvirus saimiri

Human adenoviruses

Human herpesviruses types 6, 7 & 8

Human immunodeficiency virus types 1 & 2

Human T cell lymphotropic virus

Human Varicella-Zoster

Influenza type A


Lawsonia intracellularis



Lyme disease







Neisseria gonorhoeae

Neisseria meningitidis



Plasmodium species

Reovirus screen

Rhesus rhadinovirus



Shigella and enteroinvasive E. coli

Simian agent 6 (SA6)

Simian agent 8 (SA8)

Simian foamy virus (SFV)

Simian hemorrhagic fever (SHFV)

Simian immunodeficiency virus (SIV)

Simian parainfluenza virus

Simian retrovirus (SRV)

Simian sarcoma virus

Simian T-cell leukemia (STLV) types 1 & 2

Simian T-cell leukemia (STLV) type 3

Simian Varicella-Zoster

Squirrel monkey retrovirus

Streptococcus pneumoniae

Streptococcus pyogenes





Toxoplasma gondii



Trypanosoma cruzi



Valley fever

West Nile virus (WNV)


Yellow fever

Yersinia pestis

Yersinia pseudotuberculosis

Zika virus

* * *

Genetic tests for...

A/B/AB blood type in macaques

Cynomolgus genotyping

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements

Measles PCR test for primates
primate assay data sheet

Measles (Rubeola) by PCR

Test code:
S0047 - Ultrasensitive qualitative detection of measles virus by reverse transcription coupled real time polymerase chain reaction

Measles (also known as rubeola) is an important viral disease that causes the death of about one million children each year. Measles virus belongs to the genus morbillivirus, which is a member of the paramyoxviridae family. Infection of non-human primates has been well documented in macaques (especially rhesus), baboons, African green, marmosets, tamarins, squirrel monkeys, chimps, and Presbytis cristatus. Measles viral infection seldom occurs in wild monkeys, but most wild-caught monkeys seroconvert within a few months of capture. Shedding of virus can be detected in most secretions and in urine.

Primates infected with this virus can be asymptomatic or rapidly fatal. Marmosets are said to be especially susceptible and symptoms such as maculopapular skin rash, serous to mucopurulent nasal discharge, ocular discharge and diarrhea, and rarely, abortion can develop in less than 10 days. (Koplik's spots may be present sometimes but abortion rarely occurs.) Immunosuppression during measles virus infection has also been documented and death resulting from secondary infections is common.

Many outbreaks in primate colonies have been described (Potkay et al., 1966; Willy et al., 1999; Choi et al., 1999). Although the primary infective source or the mode of infection could not be determined in a number of outbreaks, it was suspected that measles virus might have been transmitted to the monkeys from human visitors while the monkeys were on exhibit.

Although virus isolation can be used to diagnose measles virus infection, a long incubation period is required to obtain results. Furthermore, viral culture is neither sensitive nor specific, and it increases the potential risk of laboratory personnel contacting this virus. Serological detection of measles virus infection is not sensitive. In some cases, measles virus can be detected by PCR in oral fluids well before the onset of IgM antibody (Oliveira et al., 2003). The ability to detect measles virus by real time PCR in a wide variety of sample types such as urine, oral fluid and CSF not only simplifies sample acquisition procedures, but also offers multiple perspectives on the disease's progression.


  • Help confirm the disease causing agent
  • Help ensure that colonies are free of Measles virus
  • Early prevention of spread of this virus among a colony
  • Minimize personnel exposure to this virus
  • Safety monitoring of biological products and vaccines that derive from primates

Potkay, S., Ganaway, J.R., Rogers, N.G. and Kinard, R. (1966) An epizootic of measles in a colony of rhesus monkeys (Macacca mulatta). Am J Vet Res 27:331-334.
Willy, M.E., Woodward, R.A., Thornton, V.B., Wolff, A.V., Flynn, B.M., Heath, J.L., Villamarzo, Y.S., Smith, S., Bellini, W.J. and Rota, P,A, (1999) Management of a measles outbreak among Old World nonhuman primates. Lab Anim Sci. 49:42-48.
Choi, Y.K., Simon, M.A., Kim, D.Y., Yoon, B.I., Kwon, S.W., Lee, K.W., Seo, I.B. and Kim, D.Y.(1999) Fatal measles virus infection in Japanese macaques (Macaca fuscata). Vet Pathol. 36:594-600.
Oliveira, S.A., Siqueira, M.M., Camacho, L.A., Castro-Silva, R., Bruno, B.F. and Cohen, B.J.(2003) Use of RT-PCR on oral fluid samples to assist the identification of measles cases during an outbreak. Epidemiol Infect. 130:101-106.

Specimen requirement: 0.2 ml whole blood in EDTA (purple top) tube, or throat swab, or lesion swab, or lesion scab, or 0.2 ml urine, serum, plasma or CSF.

Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative reverse transcription coupled real time PCR

Normal range: Nondetected

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